Thiazole derivatives having CB1-antagonistic, agonistic or partial agonistic activity

The present invention relates to a group of thiazole derivatives which are potent antagonists, agonists or partial agonists of the cannabinoid CB1-receptor. The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification

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Bibliographic Details
Main Authors HERREMANS ARNOLDUS H. J, KRUSE CORNELIS G, VAN STUIVENBERG HERMAN H, MCCREARY ANDREW C, DIJKSMAN JESSICA A. R, LANGE JOSEPHUS H. M
Format Patent
LanguageEnglish
Published 11.03.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a group of thiazole derivatives which are potent antagonists, agonists or partial agonists of the cannabinoid CB1-receptor. The compounds have the general formula (I) wherein R and R1-R4 have the meanings given in the specification
Bibliography:Application Number: US20040490546