Triazolo-pyridines as anti-inflammatory compounds

• Main Authors: MCCLURE KIM F, BRAGANZA JOHN FREDERICK, LETAVIC MICHAEL ANTHONY
• Format: Patent
• Language: English
• Published: 22.01.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel triazolo-pyridines of the formula wherein X is >CH2, >NH, sulfur, >S-O, >SO2 or oxygen; wherein said >CH2 and >NH may optionally be substituted with a suitable substituent; R1 is selected from the group consisting of hydrogen, (C1-C6)alkyl and other suitable substituents; R2 is selected from the group consisting of hydrogen, (C1-C6)alkyl and other suitable substituents; s is an integer from 0-4; R3 is R4, R5-(NR6)-, R5-S-, R5-(S-O)-, R5-(SO2)-, R5-SO2-NR6-, R5-(NR6)-SO2-, R5-O-, R5-(C-O)-, R5-(NR6)-(C-O)-, R5-(C-O)-NR6-, R5-O-(C-O)-, R5-(C-O)-O-, R5-CR7-CR8- or R5-C≡C-; such that the molecular weight of R3 is less than 500 AMU, preferably less than 250 AMU; R4, R5 and R6 are each selected from the group consisting of hydrogen, (C1-C6)alkyl and other suitable substituents; or a pharmaceutically acceptable salt thereof; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.