Beta secretase exosite binding peptides and methods for identifying beta secretase modulators

The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BA...

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Main Authors WITMER MARK RICHARD, KORNACKER MICHAEL G, COPELAND ROBERT A, HENDRICK JOSEPH, MARCINKEVICIENE JOVITA, LAI ZHIHONG, LEE VING, RIEXINGER DOUGLAS JAMES, MAPELLI CLAUDIO, METZLER WILLIAM
Format Patent
LanguageEnglish
Published 01.01.2008
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
Bibliography:Application Number: US20030685898