Genetic engineering of vascular grafts to resist disease

• Main Authors: RADE JEFFREY J, KIM ANTONY Y, SOHN RICHARD H
• Format: Patent
• Language: English
• Published: 16.10.2007
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BANDAGES, DRESSINGS OR ABSORBENT PADS; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FISHING; FOMENTATION; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; PROSTHESES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TRAPPING; TREATMENT OR PROTECTION OF EYES OR EARS; VINEGAR; WINE

Disclosed are methods for treating a vascular graft that include introducing an effective amount of at least one nucleic acid encoding at least one agent that increases activated protein C (APC), expressing the agent in the cells; and increasing the APC sufficient to treat the blood vessel. Also provided are vascular grafts engineered to resist early and/or late graft failure.