HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis

Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts i...

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Main Authors KUCERA DAVID J, MITCHELL, JR. LENNERT J, JOSYULA VARA PRASAD, BARVIAN MARK, MURPHY SEAN T, JEWELL TANYA M, VARNEY MICHAEL D, ALEXANDER THERESE N, BOLTON GARY, VIRGIL SCOTT C, MACHAK JEFFREY J, WEBBER STEPHEN E, SKALITZKY DONALD J, CANAN KOCH STACIE S, LINTON MARIA ANGELICA, TATLOCK JOHN H, HOLLER TOD, BOYER, JR. FREDERICK EARL, MELNICK MICHAEL, BURKE BENJAMIN J, REICH SIEGFRIED H, WORLAND STEPHEN T
Format Patent
LanguageEnglish
Published 20.02.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
Bibliography:Application Number: US20020166979