Carboxypeptidase R inhibiting peptide

A novel carboxypeptidase R (CPR) inhibiting peptide is prepared using rational structure-based strategies, incorporating two principle facts: (a) CPR has a strong affinity for basic amino acids and; and (b) the two lysines and arginine residues of PCI are orientated in the same direction and held in...

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Bibliographic Details
Main Authors OKADA HIDECHIKA, LAZOURA ELIADA, CAMPBELL WILLIAM, OKADA NORIKO
Format Patent
LanguageEnglish
Published 05.12.2006
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A novel carboxypeptidase R (CPR) inhibiting peptide is prepared using rational structure-based strategies, incorporating two principle facts: (a) CPR has a strong affinity for basic amino acids and; and (b) the two lysines and arginine residues of PCI are orientated in the same direction and held in close spatial proximity by three disulfide bonds.
Bibliography:Application Number: US20020254610