Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells
Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56RB protein, a fragment of the p56RB protein, and the gene encoding p56RB protein to alter the cell cycle progression while maintaining the vi...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English |
Published |
12.09.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56RB protein, a fragment of the p56RB protein, and the gene encoding p56RB protein to alter the cell cycle progression while maintaining the viability of the cell. The p56RB protein has been found to have the unexpected and surprising characteristic of being soluble in low concentrations of glycerol, thereby enhancing its value in pharmaceutical applications and the gene encoding p56RB when delivered to the hyperproliferating cell inhibits cellular proliferation. |
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Bibliography: | Application Number: US19950472760 |