Antipicornaviral compounds, their preparation and use

Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful...

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Main Authors ZHOU RU, MARAKOVITS JOSEPH TIMOTHY, TIKHE JAYASHREE GIRISH, JOHNSON, JR. THEODORE O, PRINS THOMAS JAY, DRAGOVICH PETER SCOTT, WEBBER STEPHEN EVAN
Format Patent
LanguageEnglish
Published 14.06.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
AbstractList Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
Author ZHOU RU
DRAGOVICH PETER SCOTT
PRINS THOMAS JAY
MARAKOVITS JOSEPH TIMOTHY
JOHNSON, JR. THEODORE O
TIKHE JAYASHREE GIRISH
WEBBER STEPHEN EVAN
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– fullname: JOHNSON, JR. THEODORE O
– fullname: PRINS THOMAS JAY
– fullname: DRAGOVICH PETER SCOTT
– fullname: WEBBER STEPHEN EVAN
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Snippet Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title Antipicornaviral compounds, their preparation and use
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