Antipicornaviral compounds, their preparation and use

Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful...

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Main Authors ZHOU RU, MARAKOVITS JOSEPH TIMOTHY, TIKHE JAYASHREE GIRISH, JOHNSON, JR. THEODORE O, PRINS THOMAS JAY, DRAGOVICH PETER SCOTT, WEBBER STEPHEN EVAN
Format Patent
LanguageEnglish
Published 14.06.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
Bibliography:Application Number: US20010647712