Small-molecule inhibitors of interleukin-2

Compounds of formulae I and I', methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumato...

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Bibliographic Details
Main Authors YU CHUL HYUN, OSLOB JOHAN D, ARKIN MICHELLE R, WAAL NATHAN D, MCDOWELL ROBERT S, RAIMUNDO BRIAN C
Format Patent
LanguageEnglish
Published 19.10.2004
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds of formulae I and I', methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of IL-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.
Bibliography:Application Number: US20010024665