Electronic device for performing active biological operations and method of using same

• Main Authors: MATHER ELIZABETH L, GRAHAM SCOTT O, ACKLEY DONALD E, BUTLER WILLIAM F, LECLAIR TIMOTHY L, SWANSON PAUL D
• Format: Patent
• Language: English
• Published: 27.04.2004
• Edition: 7
• Subjects: APPARATUS THEREFOR; BASIC ELECTRIC ELEMENTS; BEER; BIOCHEMISTRY; BLASTING; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DERIVATIVES THEREOF; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR; ELECTRICITY; ENZYMOLOGY; GENERAL METHODS OF ORGANIC CHEMISTRY; HEATING; INFORMATION STORAGE; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; LIGHTING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MECHANICAL ENGINEERING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PUMPS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS; SEMICONDUCTOR DEVICES; SPIRITS; STATIC STORES; SUGARS; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WEAPONS; WINE

An electronic device for performing biological operations includes a support substrate and an array of microlocations disposed on the substrate. The array of microlocations include electronically addressable electrodes. A first collection electrode is disposed on the substrate and adjacent to a first side of the array of microlocations. A second collection electrode is disposed on the substrate and adjacent to a second side of the array of microlocations, the second side of the array being opposite of the first side such that the array of microlocations is disposed between the first and second collection electrodes. A flow cell is supported on the substrate. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell.