Carbapenem derivatives

Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against beta-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stab...

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Main Authors AKIYAMA YOSHIHISA, KANO YUKO, AIHARA KAZUHIRO, SAMBONGI YUMIKO, IWAMATSU KATSUYOSHI, MARUYAMA TAKAHISA, IDA TAKASHI, SASAKI TOSHIRO, ATSUMI KUNIO, ANDO TAKASHI, KITAGAWA HIDEO, TANABE KIYOSHI, TAKIZAWA HIROMASA
Format Patent
LanguageEnglish
Published 13.01.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against beta-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa, PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:
Bibliography:Application Number: US20020217670