Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions includ...

Full description

Saved in:
Bibliographic Details
Main Authors LINDMARK RICHARD, REITZ DAVID, NEUMANN WILLIAM L, FENTON RICK, LONG SCOTT A, CASE BRENDA, RUEPPEL MELVIN L, TRUJILLO JOHN I, SOUTH MICHAEL, DICE TOM, ZENG QINGPING, PARLOW JOHN J, HAYES MICHAEL J, WANG CHINGNG, FRANKLIN GARY W, WOOD RHONDA, HUANG HORNGIH, KUSTURIN CARRIE, JONES DARIN E, HUANG WEI, MAHONEY MATTHEW
Format Patent
LanguageEnglish
Published 16.12.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
Bibliography:Application Number: US20000574752