Modulators of protein tyrosine phosphatases (PTPases)

The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP,wherein X, R1, R2,...

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Main Authors OLSEN OLE HVILSTED, SHAPIRA BARRY ZVI, GE YU, BAKIR FARID, HOLSWORTH DANIEL DALE, UYEDA ROY TERUYUKI, MOLLER NIELS PETER HUNDAHL, NEWMAN MICHAEL JAMES, LAU JESPER, HANSEN THOMAS KRUSE, ANDERSEN HENRIK SUNE, AXE FRANK URBAN, JUDGE LUKE MILBURN
Format Patent
LanguageEnglish
Published 02.09.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP,wherein X, R1, R2, R3, and R4 are defined more fully in the description. The compounds are useful in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.
Bibliography:Application Number: US20010901367