Derivatives of polyene macrolides and preparation and use thereof
The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, th...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
13.05.2003
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME. |
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Bibliography: | Application Number: US20010026853 |