Tricyclic biphenyl sulfonamide matrix metalloproteinase inhibitors

Matrix metalloproteinase inhibitors are tricyclic sulfonamides of the Formula Ior a pharmaceutically acceptable salt thereof,wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 is OH or NHOH; X is O or S(O)n; n is 0, 1, or 2; p is 0, 1, 2, or 3; - is absent or a bond; and the sulfur...

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Bibliographic Details
Main Authors O'BRIEN PATRICK MICHAEL, SLISKOVIC DRAGO ROBERT
Format Patent
LanguageEnglish
Published 29.04.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Matrix metalloproteinase inhibitors are tricyclic sulfonamides of the Formula Ior a pharmaceutically acceptable salt thereof,wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 is OH or NHOH; X is O or S(O)n; n is 0, 1, or 2; p is 0, 1, 2, or 3; - is absent or a bond; and the sulfur atom bearing (O)q is bonded to the benzo ring at position a or position b.
Bibliography:Application Number: US20020075431