Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1The compounds are useful in treating elevated levels of endothelin, essential...

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Main Authors LEE CHITASE, SKEEAN RICHARD WILLIAM, BUNKER AMY MAE, KANTER GERALD DAVID, EDMUNDS JEREMY JOHN, CHENG XUE-MIN, DOHERTY ANNETTE MARIAN, REPINE JOSEPH THOMAS
Format Patent
LanguageEnglish
Published 08.04.2003
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Bibliography:Application Number: US20010006589