Imidazotriazolopyrimidines with adenosine-antagonistic activity

New imidazotriazolopyrimidine derivatives of the formulaPreferred are those compounds wherein:R1 denotes methyl, which is optionally substituted by phenyloxy or pyrrole; orR1 denotes benzyl which is optionally substituted by hydroxy, methoxy, dimethylaminoethoxy or fluorine; or R1 denotes cyclopenty...

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Main Authors KUEFNER-MUEHL ULRIKE, MIERAU JOACHIM, BLECH STEFAN, HOFFMANN MATTHIAS, MEADE CHRISTOPHER JOHN MONTAGUE, POHL GERALD, WEISER THOMAS, LEHR ERICH, CARTER ADRIAN, KUMMER WERNER, GAIDA WOLFRAM
Format Patent
LanguageEnglish
Published 10.12.2002
Edition7
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Summary:New imidazotriazolopyrimidine derivatives of the formulaPreferred are those compounds wherein:R1 denotes methyl, which is optionally substituted by phenyloxy or pyrrole; orR1 denotes benzyl which is optionally substituted by hydroxy, methoxy, dimethylaminoethoxy or fluorine; or R1 denotes cyclopentyl, furan or phenylethyl;R2 or R3 denote ethyl, n-propyl, allyl or propargyl;R4 or R6 denote hydrogen; and,R5 denotes methyl, n-propyl, tert.butyl, cyclopentyl or norbornenyl.These are adenosine antagonists are are useful for, inter alia, the treatment of senile dementia of the Alzheimer's type.
Bibliography:Application Number: US20000559806