Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors

Disclosed are an enhancer, insulator, and promoter from the HS5 region in the 5' boundary area of the locus control region of human beta-like globin genes. These transcription control sequences can be used to control expression of any desired gene of interest and can be used in any vector for t...

Full description

Saved in:
Bibliographic Details
Main Authors LONG QIAOMING, BENGRA CHIKH, TUAN DOROTHY
Format Patent
LanguageEnglish
Published 28.05.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Disclosed are an enhancer, insulator, and promoter from the HS5 region in the 5' boundary area of the locus control region of human beta-like globin genes. These transcription control sequences can be used to control expression of any desired gene of interest and can be used in any vector for this purpose. The control sequences are derived from the area in and around the U3 region of a solitary endogenous retrovirus (ERV) 9 long terminal repeat (LTR). Also disclosed are methods of expressing any gene of interest. For this purpose, the control sequences can be operably linked to the gene of interest (and operably linked to each other). The disclosed enhancers, insulators, and promoters can also be used with any other control sequences. Preferably, the control sequences are used in vectors to obtain expression of a gene of interest in a cell, including cells in animals.
Bibliography:Application Number: US19990422576