Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors

The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In p...

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Main Authors DICKERSON SCOTT HOWARD, HUNTER, III ROBERT NEIL, LACKEY KAREN ELIZABETH, HARRIS PHILIP ANTHONY, DAVIS STEPHEN THOMAS, KUYPER LEE FREDERICK, VEAL JAMES MARVIN, WALKER DUNCAN HERRICK, LUZZIO MICHAEL JOSEPH
Format Patent
LanguageEnglish
Published 09.04.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit protein tyrosine kinase and protein serine/threonine kinase inhibition, and which are useful in inhibiting tumor growth via inhibition of such kinases as well as protecting a patient undergoing chemotherapy from chemotherapy induced alopecia.
Bibliography:Application Number: US19990262351