Hexahydro-1,4-diazepine derivatives or salts thereof

Hexahydro-1,4-diazepine derivatives represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs containing the same as the active ingredient, such as activated blood coagulation factor X inhibitor, wherein A: phenylene, pyridylene, or the like; B: a 5- or 6-membered aryl...

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Main Authors ISHIHARA TSUKASA, MATSUMOTO YUZO, KAWASAKI TOMIHISA, HIRAYAMA FUKUSHI, FUNATSU MASASHI, KOSHIO HIROYUKI
Format Patent
LanguageEnglish
Published 25.12.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Hexahydro-1,4-diazepine derivatives represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs containing the same as the active ingredient, such as activated blood coagulation factor X inhibitor, wherein A: phenylene, pyridylene, or the like; B: a 5- or 6-membered aryl or heteroaryl ring; X: -CO-, -CONH-, -CSNH-, -SO2-, -SO2NH-, or the like; Y: a bond or alkylene; R1: hydrogen, alkyl, -Y-(hetero) aryl, or the like; R2: hydrogen, alkoxy, -COOH, or the like; R3: amidino or a group capable of being converted into amidino; and R4, R5: each independently hydrogen or lower alkyl.
Bibliography:Application Number: US20000463017