Methods for treating or preventing alzheimer's disease using substituted 1-aryl-3-piperazin-1'-yl propanones

• Main Authors: DEBERNARDIS JOHN FRANCIS, KERKMAN DANIEL JOSEPH, ZINKOWSKI RAYMOND PAUL
• Format: Patent
• Language: English
• Published: 23.10.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of formula I:or the pharmaceutically acceptable salts thereof whereinX is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl;Z is nitrogen or CH;Ar1 and Ar2 independently represent aryl groups; andY is hydrogen; orY and R1 or R2 toget...