Methods for treating or preventing alzheimer's disease using substituted 1-aryl-3-piperazin-1'-yl propanones
Disclosed are compounds of formula I:or the pharmaceutically acceptable salts thereof whereinX is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl;Z is nitrogen or CH;Ar1 and Ar2 independently represent aryl groups; andY is hydrogen; orY and R1 or R2 toget...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
23.10.2001
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Disclosed are compounds of formula I:or the pharmaceutically acceptable salts thereof whereinX is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl;Z is nitrogen or CH;Ar1 and Ar2 independently represent aryl groups; andY is hydrogen; orY and R1 or R2 together represent CH2; CH2CH2; CH20; CH2S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and for preventing or decreaseing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore for treating Alzheimer's Disease. |
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Bibliography: | Application Number: US19990371667 |