Depsipeptide derivatives bearing piperazinone rings

The present invention provides a new depsipeptide derivative having a piperazinone ring within the molecule which is represented by formula (1)whereinX1 represents N(R4)-CO, N(R5)-CH2, CH2-CO, CH2-CH2, CH=CH, CH2-CH(OH) or CH(OH)-CH(OH), R1 represents a C5-C20 alkyl group or a C5-C15 alkoxy C1-C4 al...

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Main Authors YASUDA ORIE, YANAI MAKOTO, SUZUKI MASASHI, OSHIDA NORIO, TAKASU MASAKO, SHINGAI AKIKO, KAWAMURA KOJI, HIRAMOTO SHIGERU, KINOSHITA NOBUHIRO
Format Patent
LanguageEnglish
Published 11.09.2001
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a new depsipeptide derivative having a piperazinone ring within the molecule which is represented by formula (1)whereinX1 represents N(R4)-CO, N(R5)-CH2, CH2-CO, CH2-CH2, CH=CH, CH2-CH(OH) or CH(OH)-CH(OH), R1 represents a C5-C20 alkyl group or a C5-C15 alkoxy C1-C4 alkyl group, R2-R5 represent a hydrogen atom or a C1-C6 alkyl group, andA represents a group of formula (2), (3) or (4)The depsipeptide derivative has a function of accelerating the production of apolipoprotein E and is useful as an agent for the treatment of neurologic injury, an agent for the treatment of dementia and an antihyperlipidemic agent.
Bibliography:Application Number: US20000509132