Depsipeptides containing non-natural amino acids

• Main Authors: YASUDA ORIE, YANAI MAKOTO, SUZUKI MASASHI, OSHIDA NORIO, TAKASU MASAKO, SHINGAI AKIKO, KAWAMURA KOJI, HIRAMOTO SHIGERU, KINOSHITA NOBUHIRO
• Format: Patent
• Language: English
• Published: 26.06.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

A depsipeptide containing a non-natural amino acid(s) having the formula (1)wherein R1 represents a C5-C20 alkyl group and others; R2 represents -O-CO-CH(R5)-X-CH(R6)-NH- (wherein X represents N(R7)-CO, CH2-CO, CH2-CH2 and others, R5, R6, and R7 represent a hydrogen atom or a C1-C6 alkyl group); R3 representsand wherein the remaining substituent variables are as defined herein.The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.