Cyanine dyes and synthesis methods thereof

A cyanine dye having the formulawherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of...

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Main Authors BUZBY PHILIP RICHARD, AHERN DAVID GEORGE, ERICKSON THOMAS JOSEPH, MILLER, JR. JOSEPH JOHN, RANDALL MALCOLM HARRY, TROMETER JOSEPH DAVID, BOBROW MARK NORMAN
Format Patent
LanguageEnglish
Published 01.05.2001
Edition7
Subjects
ADHESIVES
CHEMISTRY
DYES
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
LAKES
MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MISCELLANEOUS APPLICATIONS OF MATERIALS
MISCELLANEOUS COMPOSITIONS
MORDANTS
NATURAL RESINS
ORGANIC CHEMISTRY
ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES
PAINTS
PHYSICS
POLISHES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:A cyanine dye having the formulawherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.
Bibliography:Application Number: US19990448242