Glucose-6-phosphate dehydrogenase deficient mice and methods of using same

Mice which produce measurable levels of glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells can be used as animal models to evaluate new drugs for risk of inducing hemolytic anemia in G6PD-deficient individuals, and for pre-clinical evaluation of gene therapy protocols to correct G6PD...

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Bibliographic Details
Main Authors LONGO; LETIZIA, LUZZATTO; LUCIO
Format Patent
LanguageEnglish
Published 30.05.2000
Edition7
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPIRITS
TRAPPING
VINEGAR
WINE
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Summary:Mice which produce measurable levels of glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells can be used as animal models to evaluate new drugs for risk of inducing hemolytic anemia in G6PD-deficient individuals, and for pre-clinical evaluation of gene therapy protocols to correct G6PD deficiency. Deficient and wild-type cells can be distinguished using a tetrazolium dye, and the numbers of each type of cell counted before and after exposure of the cells to the drug or therapy.
Bibliography:Application Number: US19970985758