Oligonucleotide analogs, their preparation and use

The invention relates to compounds of the formula I where R1 is H, alkyl, acyl, aryl, or a phosphate residue; R2 is H, OH, alkoxy, NH2, or halogen; B is a base customary in nucleotide chemistry; a is O or CH2; n is an integer from 1 to 100; W=O, S or Se; V=O, S, or NH; Y=O, S, NH, or CH2; Y'=O,...

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Bibliographic Details
Main Authors HELSBERG; MATTHIAS, O'MALLEY; GERARD, WINKLER; IRVIN, PEYMAN; ANUSCHIRWAN, UHLMANN; EUGEN
Format Patent
LanguageEnglish
Published 07.03.2000
Edition7
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention relates to compounds of the formula I where R1 is H, alkyl, acyl, aryl, or a phosphate residue; R2 is H, OH, alkoxy, NH2, or halogen; B is a base customary in nucleotide chemistry; a is O or CH2; n is an integer from 1 to 100; W=O, S or Se; V=O, S, or NH; Y=O, S, NH, or CH2; Y'=O, S, NH, or alkylene; X=OH or SH; U=OH, SH, SeH, alkyl, alkoxy, aryl, aryloxy, or amine, and Z=OH, SH, SeH, an optionally substituted radical from the group comprising alkyl, aryl, heteroaryl, alkoxy, or amino, or a group which favors intracellular uptake or serves as the label of a DNA probe or attacks the target nucleic acid during hybridization, where if Z=OH, SH, CH3, or OC2H5, at least one of the groups X, Y, Y', V, or W is not OH or O or R1 is not H; a process for their preparation and their use as inhibitors of gene expression, as probes for detecting nucleic acids and as aids in molecular biology.
Bibliography:Application Number: US19940281203