Dihydropyridine NPY antagonists: cyanoguanidine derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight...

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Main Authors SWANN; R. THOMAS, MORTON; MENDI A, BREITENBUCHER; JAMES GUY, HUANG; YAZHONG, BRUCE; MARC A, SIT; SING-YUEN, POINDEXTER; GRAHAM S
Format Patent
LanguageEnglish
Published 14.12.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
Bibliography:Application Number: US19980084692