Biocompatible polymeric materials, methods of preparing such materials and uses thereof

• Main Authors: BAGROV; SERGEI NIKOLAYEVICH, FEDOROV; SVYATOSLAV NIKOLAYEVICH, MAKLAKOVA; IRINA ALEKSANDROVNA, NOVIKOV; SERGEI VIKTOROVICH, SHELUKHINA; GALINA DMITRIYEVNA
• Format: Patent
• Language: English
• Published: 30.11.1999
• Edition: 6
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; CONTACT LENSES; DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS; OPTICS; ORGANIC MACROMOLECULAR COMPOUNDS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PHYSICS; PROSTHESES; SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURESAS SPECTACLES; THEIR PREPARATION OR CHEMICAL WORKING-UP; TREATMENT OR PROTECTION OF EYES OR EARS

The present invention is directed to a biocompatible polymeric material and methods of making prepared by forming a mixture of collagen, a water-soluble ethylenically unsaturated compound and a cross-linking agent at a temperature of 30 DEG C. to 42 DEG C.; adjusting the pH of the mixture to 3.2 to 5.0; and polymerizing the mixture. The resulting material is rinsed in a physiologic solution at a temperature of 25 DEG C. to 80 DEG C. The resulting polymeric material has a modules of elasticity in the range of 10 to 27x105 N/m2. Mechanical strength of the polymeric material is 20 to 100 times greater than polymeric material prepared by known methods. The material is optically transparent and is characterized by 95% or more light transmission in the visible spectrum and by resolution of 200 lines per mm for a +20D intraocular lens. The material is characterized by low protein absorption of about 0.1x10-3 mu g/mg and the material is resistant to proteolytic enzymes including pepsin, trypsin, chymotrypsin, and collagenase. The present invention is further directed to intraocular lenses and contact lenses produced from the present material, and the use of such lenses in patients having impaired vision to correct or improve such impaired vision.