Derivatives of 3-pyrrolidylidene-2-one-cephalosporines

PCT No. PCT/EP96/00667 Sec. 371 Date Jul. 25, 1997 Sec. 102(e) Date Jul. 25, 1997 PCT Filed Feb. 16, 1996 PCT Pub. No. WO96/26943 PCT Pub. Date Sep. 6, 1996Compounds of formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R3CO- or -C(R4R5)CO2R6; where R4 and R5 are each independentl...

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Bibliographic Details
Main Authors RICHTER; HANS, HEINZE-KRAUSS; INGRID
Format Patent
LanguageEnglish
Published 20.07.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/EP96/00667 Sec. 371 Date Jul. 25, 1997 Sec. 102(e) Date Jul. 25, 1997 PCT Filed Feb. 16, 1996 PCT Pub. No. WO96/26943 PCT Pub. Date Sep. 6, 1996Compounds of formula (I) wherein R1 is hydrogen, lower alkyl, aralkyl, cycloalkyl, R3CO- or -C(R4R5)CO2R6; where R4 and R5 are each independently hydrogen or lower alkyl, or R4 and R5 taken together with the carbon atom to which they are attached form a cycloalkyl group; R3 is hydrogen or lower alkyl and R6 is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group; R2 is isobutyl, 2,2-dimethyl-propyl or cyclohexyl-methyl; n is 0, 1 or 2; X is CH or N; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts are disclosed. These compounds have valuable antibacterial activity.
Bibliography:Application Number: US19970875563