Platinum (IV) complex and pharmaceutical composition comprising the same

A diamine-platinum (IV) complex represented by the following formula (1): wherein R1 and R2 together represent R5O-CH(CH2NH2)2 (R5 represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C5-8 1,2-cycloalkanediamine; R3 and R4 each represents hydrogen or R6C...

Full description

Saved in:
Bibliographic Details
Main Authors OHTSUKA; MARI, MOGI; KINICHI, KOYA; HIDEHIKO, SATO; SUSUMU, MIZUNO; HIROYUKI
Format Patent
LanguageEnglish
Published 11.05.1999
Edition6
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:A diamine-platinum (IV) complex represented by the following formula (1): wherein R1 and R2 together represent R5O-CH(CH2NH2)2 (R5 represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C5-8 1,2-cycloalkanediamine; R3 and R4 each represents hydrogen or R6CO- (R6 represents alkyl, halogenoalkyl, cycloalkyl, aryl or aralkyl); and two X's together represent a malonic acid residue or glycolic acid residue which may have a substituent capable of coordinating to the platinum in formula (1) by an O,O-coordination or an N-acylamino acid residue coordinating to the platinum in formula (1) by an O,N-coordination; and a pharmaceutical composition comprising as an active ingredient the above-described diamine-platinum (IV) complex.
Bibliography:Application Number: US19970997061