Phosphonomonoester nucleic acids, process for their preparation, and their use

Novel oligonucleotide analogs of the formula (I) are described, (I) in which A, B, D, G, L, P, Q, Q', R5, R6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application rel...

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Bibliographic Details
Main Authors WALLMEIER; HOLGER, PEYMAN; ANUSCHIRWAN, BREIPOHL; GERHARD, UHLMANN; EUGEN
Format Patent
LanguageEnglish
Published 23.02.1999
Edition6
Subjects
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Summary:Novel oligonucleotide analogs of the formula (I) are described, (I) in which A, B, D, G, L, P, Q, Q', R5, R6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology. Novel oligonucleotide analogs of the formula (I) are described, (I) in which A, B, D, G, L, P, Q, Q', R5, R6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology.
Bibliography:Application Number: US19960613417