Process for the resolution of rac-2-oxotricycloÄ2.2.1.0 3,5Ü heptane-7-carboxylic acid esters using lipase from candida

Process for the resolution of rac-2-oxotricyclo[2.2.1.03,5]heptane-7-carboxylic acid esters using lipase from candida. Compounds of the formula I (I) in which R1 has the meanings mentioned, may be obtained in isomerically pure form from enantiomer mixtures or racemic mixtures by reacting the compoun...

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Bibliographic Details
Main Authors HOLLA; WOLFGANG, BECK; GERHARD
Format Patent
LanguageEnglish
Published 19.01.1999
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Process for the resolution of rac-2-oxotricyclo[2.2.1.03,5]heptane-7-carboxylic acid esters using lipase from candida. Compounds of the formula I (I) in which R1 has the meanings mentioned, may be obtained in isomerically pure form from enantiomer mixtures or racemic mixtures by reacting the compound of the formula I in the presence of a lipase or esterase from porcine liver, porcine pancreas, bovine pancreas or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus, or proteases from Bacillus in the presence of water and, if desired, a cosolvent and separating from one another the esters and acids present in the solution obtained.
Bibliography:Application Number: US19970932933