Hydroxamic acid derivatives as inhibitors of cytokine production

PCT No. PCT/GB94/02145 Sec. 371 Date Oct. 28, 1996 Sec. 102(e) Date Oct. 28, 1996 PCT Filed Oct. 4, 1994 PCT Pub. No. WO95/09841 PCT Pub. Date Apr. 13, 1995A compound of formula (I): (I) wherein: R1 represents a (C1-C6)alkyl, phenyl, substituted phenyl, or heterocyclyl group; R2 represents a (C1-C6)...

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Bibliographic Details
Main Authors CRIMMIN; MICHAEL JOHN, BECKETT; RAYMOND PAUL
Format Patent
LanguageEnglish
Published 13.10.1998
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/GB94/02145 Sec. 371 Date Oct. 28, 1996 Sec. 102(e) Date Oct. 28, 1996 PCT Filed Oct. 4, 1994 PCT Pub. No. WO95/09841 PCT Pub. Date Apr. 13, 1995A compound of formula (I): (I) wherein: R1 represents a (C1-C6)alkyl, phenyl, substituted phenyl, or heterocyclyl group; R2 represents a (C1-C6)alkyl group; R3 represents: (I) the side chain of arginine, lysine, tryptophan, histidine, serine, threonine, or cysteine, in which any polar amino, hydroxy, mercapto, guanidyl, imidazolyl or indolyl group is rendered substantially non-polar by substitution at the polar N-, O- or S-atom; or (ii) the side chain of aspartic or glutamic acid, in which side chain the carboxylic acid group is amidated; R4 represents hydrogen or a (C1-C6)alkyl or phenyl (C1-C6)alkyl group; R5 represents hydrogen or and n is 0, 1 or 2; or substituted phenyl groups; or a salt solvate or hydrate thereof. Compositions containing compound (I) and methods for treatment of diseases or conditions mediated by TNF or MMPs in mammals.
Bibliography:Application Number: US19960615184