Quinazoline derivatives

• Main Authors: KIMURA; TEIJI, TAKASE; YASUTAKA, WATANABE; NOBUHISA, SAEKI; TAKAO, AKITA; YASUNORI, MATSUI; MAKOTO, IKUTA; HIRONORI, ADACHI; HIDEYUKI, MOCHIDA; HISATOSHI, SOUDA; SHIGERU, TOKUMURA; TADAKAZU
• Format: Patent
• Language: English
• Published: 01.09.1998
• Edition: 6
• Subjects: BEARINGS; BLASTING; CHEMISTRY; ELEMENTS OR CRANKSHAFT MECHANISMS; ENGINEERING ELEMENTS AND UNITS; FLEXIBLE SHAFTS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVEFUNCTIONING OF MACHINES OR INSTALLATIONS; HEATING; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; LIGHTING; MECHANICAL ENGINEERING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; ROTARY BODIES OTHER THAN GEARING ELEMENTS; SERVICING, CLEANING, REPAIRING, SUPPORTING, LIFTING, ORMANOEUVRING OF VEHICLES, NOT OTHERWISE PROVIDED FOR; SHAFTS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THERMAL INSULATION IN GENERAL; TRANSPORTING; VEHICLES IN GENERAL; WEAPONS

The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: (1) [in formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring; ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R1, R2, R3 and R4 represent each a hydrogen atom, a halogen atom or a group such as a lower alkoxy group; R5 represents a group represented by the formula -NR11R12 (wherein R11 and R12 represent each a hydrogen atom or a group such as a lower alkyl group) or the like; and R6 represents a group represented by the formula (wherein R19 represents a hydrogen atom, a lower alkyl group or the like; R20, R21 and R22 represent each a hydrogen atom, a halogen atom, a hydroxyl group or the like; and r represents 0 or an integer of 1 to 8)].