Cyclic compounds, their prudiction and use

• Main Authors: DOI; TAKAYUKI, KIMURA; CHIHARU, TARUI; NAOKI, ISHIMARU; TAKENORI, IKEURA; YOSHINORI, NATSUGARI; HIDEAKI
• Format: Patent
• Language: English
• Published: 23.06.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Novel compounds of the following general formula or salts thereof. wherein Ring M is a heterocyclic ring having -N=C<, -CO-N< or -CS-N< as the partial structure -X +E,ovs . . .+EE Y<; Ra and Rb are bonded to each other to form Ring A, or they are the same or different and represent, independently, a hydrogen atom or a substituent on the Ring M; Ring A and Ring B represent, independently, an optionally substituted homocyclic or heterocyclic ring, and at least one of them is optionally substituted heterocyclic ring; Rng C is optionally substituted homocyclic or heterocyclic ring; Rng Z is an optionally substituted ring; and n represents an integer of from 1 to 6, or a salt thereof, which has anexcellent tachykinin receptor antagonistic effect, and their production, and pharmaceutical compositions. Novel compounds of the following general formula or salts thereof. wherein Ring M is a heterocyclic ring having -N=C<, -CO-N< or -CS-N< as the partial structure -X +E,ovs . . .+EE Y<; Ra and Rb are bonded to each other to form Ring A, or they are the same or different and represent, independently, a hydrogen atom or a substituent on the Ring M; Ring A and Ring B represent, independently, an optionally substituted homocyclic or heterocyclic ring, and at least one of them is optionally substituted heterocyclic ring; Rng C is optionally substituted homocyclic or heterocyclic ring; Rng Z is an optionally substituted ring; and n represents an integer of from 1 to 6, or a salt thereof, which has anexcellent tachykinin receptor antagonistic effect, and their production, and pharmaceutical compositions.