Compositions for inhibition of intracellular transcription factors and methods therefor

PCT No. PCT/US94/12095 Sec. 371 Date Jul. 2, 1996 Sec. 102(e) Date Jul. 2, 1996 PCT Filed Oct. 21, 1994 PCT Pub. No. WO95/11312 PCT Pub. Date Apr. 27, 1995Novel compositions and methods for inhibiting cytokine-induced intracellular activation of STAT family transcription factors by binding to the tr...

Full description

Saved in:
Bibliographic Details
Main Authors FARRAR; MICHAEL A, SCHREIBER; ROBERT D, GREENLUND; ANDREW C
Format Patent
LanguageEnglish
Published 24.03.1998
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:PCT No. PCT/US94/12095 Sec. 371 Date Jul. 2, 1996 Sec. 102(e) Date Jul. 2, 1996 PCT Filed Oct. 21, 1994 PCT Pub. No. WO95/11312 PCT Pub. Date Apr. 27, 1995Novel compositions and methods for inhibiting cytokine-induced intracellular activation of STAT family transcription factors by binding to the transcription factors and inhibiting the transcriptional activity of the factors are disclosed. The method comprises introducing into a cell an effective amount of a peptide or derivative thereof, in which the peptide contains a sequence that is derived from a receptor for the cytokine, but with a tyrosine residue being phosphorylated. The compositions comprise isolated peptides or derivatives thereof in which the peptide contains an amino acid sequence derived from a receptor for a cytokine but with a tyrosine residue phosphorylated. A method for identifying derivatives of the isolated peptides comprising detecting the inhibition of the binding of said peptide to a STAT family transcription factor by said derivative is also provided.
Bibliography:Application Number: US19960633772