7-acyl-3-(substituted carbamoyloxy) cephem compounds and process for their preparation

• Main Authors: KATSU; KANEMASA, NEGI; SHIGETO, MACHIDA; YOSHIMASA, SUGIYAMA; ISAO, KOMATU; YUUKI, TSURUOKA; AKIHIKO, YAMANAKA; MOTOSUKE, KAMATA; ATSUSHI
• Format: Patent
• Language: English
• Published: 24.12.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): (1) wherein A means a -CH= or -N= group; R1 denotes a hydroxyl, lower alkoxyl, fluorine-substituted lower alkoxyl or protected hydroxyl group; R2 and R3 are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R2 is a hydrogen atom and R3 is a lower alkoxyl or alkyl group optionally substituted by one or more halogen atoms, or the group means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said heterocyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R4 denotes a carboxyl or protected carboxyl group; or a pharmaceutically acceptable salt thereof; and a process for the preparation thereof; as well as an antibacterial composition containing the above cephem compound. A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): (1) wherein A means a -CH= or -N= group; R1 denotes a hydroxyl, lower alkoxyl, fluorine-substituted lower alkoxyl or protected hydroxyl group; R2 and R3 are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R2 is a hydrogen atom and R3 is a lower alkoxyl or alkyl group optionally substituted by one or more halogen atoms, or the group means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said heterocyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R4 denotes a carboxyl or protected carboxyl group; or a pharmaceutically acceptable salt thereof; and a process for the preparation thereof; as well as an antibacterial composition containing the above cephem compound.