Alcohols and ethers with aromatic substituents as tachykinin-antagonists

PCT No. PCT/GB93/01863 Sec. 371 Date Mar. 10, 1995 Sec. 102(e) Date Mar. 10, 1995 PCT Filed Sep. 3, 1993 PCT Pub. No. WO94/15625 PCT Pub. Date Mar. 17, 1994 (I) Compounds of formula (I), and salt and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; R1 is H; optionally subs...

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Bibliographic Details
Main Authors STEVENSON; GRAEME I, WILLIAMS; BRAIN J, HUSCROFT; IAN T
Format Patent
LanguageEnglish
Published 08.10.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PCT No. PCT/GB93/01863 Sec. 371 Date Mar. 10, 1995 Sec. 102(e) Date Mar. 10, 1995 PCT Filed Sep. 3, 1993 PCT Pub. No. WO94/15625 PCT Pub. Date Mar. 17, 1994 (I) Compounds of formula (I), and salt and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; R1 is H; optionally substituted C1-6alkyl; optionally substituted phenyl(C1-4alkyl); C2-6alkenyl; C2-6alkynyl; CORa; COORa; COHet; COC1-6alkylhalo; COC1-6alkylNRaRb; CONR12C1-6alkylCONRaRb; CONRaRb; or SO2Ra; R2 represents H, C1-6alkyl or C2-6alkenyl; or R1 and R2 together form a chain (CH2)q optionally substituted by oxo where q is 4 or 5 and where one methylene group may optionally be replaced by an oxygen atom or a group NRx, where Rx is H or C1-6alkyl; R3 is C1-3alkyl substituted by optionally substituted phenyl; R4 and R5 are each H, C1-6alkyl or C2-6alkenyl; and Z represents O or S; are tachykinin receptor antagonists useful in therapy.
Bibliography:Application Number: US19950397224