3,4-substituted pyrazoles for the treatment of inflammation

A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: (II) wherein R1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, aryla...

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Bibliographic Details
Main Authors KRAMER; STEVEN W, LEE; LEN F, PENNING; THOMAS D
Format Patent
LanguageEnglish
Published 23.01.1996
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: (II) wherein R1 is selected from hydrido, alkyl, alkenyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R3 is aryl substituted at a substitutable position with halo; wherein R4 is selected from hydrido and haloalkyl; and wherein R5 is selected from alkyl and amino; or a pharmaceutically-acceptable salt or prodrug thereof.
Bibliography:Application Number: US19940278297