Compositions of iodophenyl esters and iodophenyl sulfonates and pharmaceutically acceptable clays for visualization of the gastrointestinal tract

• Main Authors: COOPER; EUGENE R, ESTEP; KIMBERLY G, RUDDY; STEPHEN B, ROBERTS; MARY E, MCINTIRE; GREGORY L
• Format: Patent
• Language: English
• Published: 05.12.1995
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Disclosed are x-ray contrast compositions of the formula wherein X is or -SO2-; Z is H, halo, methyl, ethyl, n-propyl, C4-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R is C1-C25 alkyl, cycloalkyl or aryl each of which may be optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy; n is 1-5; y is 0-4; and w is 1-4; in combination with a pharmaceutically acceptable clay; and method for their use in diagnostic radiology of the gastrointestinal tract. Disclosed are x-ray contrast compositions of the formula wherein X is or -SO2-; Z is H, halo, methyl, ethyl, n-propyl, C4-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R is C1-C25 alkyl, cycloalkyl or aryl each of which may be optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy; n is 1-5; y is 0-4; and w is 1-4; in combination with a pharmaceutically acceptable clay; and method for their use in diagnostic radiology of the gastrointestinal tract.