Use of aryl hydroxyurea compounds for the treatment of atherosclerosis

• Main Author: GARLAND; LAWRENCE G
• Format: Patent
• Language: English
• Published: 24.10.1995
• Edition: 6
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention is concerned with the use of a compound of formula (I): Ar-Y-Q, wherein Ar is either (i) furyl, thienyl, thienyl 1,1-dioxide, pyrryl, pyridyl, benzofuryl, benzothienyl, benzothienyl 1,1-dioxide, indolyl, naphthyl, quinolyl, or tetrahydronaphthyl, any of which is optionally substituted by one or more substituents independently selected from C1-4 alkyl (which may itself optionally be substituted by one or more halogen atoms), C1-4 alkoxy, halo, nitro, amino, carboxy, C1-4 alkoxy-carbonyl and hydroxy, or (ii) phenyl optionally substituted by one or more substituents independently selected from phenyl (which is itself optionally substituted by one or more substituents independently selected from those optional substituents specified in (i) above) and those specified as optional substituents in (i) above, Y is C1-10 alkylene or C2-10 alkenylene; Q is formula (II), where R1 is hydrogen, C1-4 alkyl, a group as defined for Ar above, or a group of formula -N(R4)R5 wherein R4 is hydrogen or C1-4 alkyl and R5 is hydrogen, C1-4 alkyl, or phenyl optionally substituted by one or more substituents independently selected from those specified as optional substituents in (i) above; and R2 is hydrogen, C1-4 alkyl, amino, C1-4 alkylamino, di-C1-4 alkylamino, C5-7 cycloalkylamino, C5-7 cycloalkyl(C1-4 alkyl)-amino, anilino, N-C1-4 alkylanilino, or a group as defined for Ar above; or a physiologically acceptable base salt or physiologically functional derivative thereof; in the manufacture of a medicament for the prophylaxis and treatment of conditions for which inhibition of the oxidative modification of lipids is indicated, for example, atherosclerosis. The medicaments obtained thereby and their preparation and use in the prophylaxis and treatment of the aforementioned conditions are also within the scope of the invention.