Receptor membranes

PCT No. PCT/AU88/00273 Sec. 371 Date Jan. 25, 1990 Sec. 102(e) Date Jan. 25, 1990 PCT Filed Jul. 27, 1988 PCT Pub. No. WO89/01159 PCT Pub. Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in tha...

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Bibliographic Details
Main Authors CORNELL; BRUCE A, BRAACH-MAKSVYTIS; VIJOLETA L. B
Format Patent
LanguageEnglish
Published 25.07.1995
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SEPARATION
SPIRITS
TESTING
TRANSPORTING
VINEGAR
WINE
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Summary:PCT No. PCT/AU88/00273 Sec. 371 Date Jan. 25, 1990 Sec. 102(e) Date Jan. 25, 1990 PCT Filed Jul. 27, 1988 PCT Pub. No. WO89/01159 PCT Pub. Date Feb. 9, 1989.The present invention provides a membrane comprising a closely packed array of self-assembly amphiphilic molecules, and is characterized in that it incorporates plurality of ion channels, and/or at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, coronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes, enzymes and lectins. The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at an end remote from the receptor site. In preferred embodiments the ion channel is gramicidin A, and is preferably gated. Such membranes may be used in the formation of sensing devices.
Bibliography:Application Number: US19900473932