6-0-methylerythromycin A derivatives

PCT No. PCT/JP91/01608 Sec. 371 Date May 20, 1993 Sec. 102(e) Date May 20, 1993 PCT Filed Nov. 22, 1991 PCT Pub. No. WO92/09614 PCT Pub. Date Jun. 11, 1992.This invention provides 6-O-methylerythromycin A derivatives represented by the following formula (wherein R1 and R2 each represent a hydrogen a...

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Bibliographic Details
Main Authors MORIMOTO; SHIGEO, HATAYAMA; KATSUO, KASHIMURA; MASATO, ASAKA; TOSHIFUMI
Format Patent
LanguageEnglish
Published 04.04.1995
Edition6
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:PCT No. PCT/JP91/01608 Sec. 371 Date May 20, 1993 Sec. 102(e) Date May 20, 1993 PCT Filed Nov. 22, 1991 PCT Pub. No. WO92/09614 PCT Pub. Date Jun. 11, 1992.This invention provides 6-O-methylerythromycin A derivatives represented by the following formula (wherein R1 and R2 each represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and A represents a nitrogen atom or a N->O group) and their pharmaceutically acceptable salts. The erythromycin A derivatives have a strong antimicrobial activity against Gram-negative bacteria and have a much stronger activity against Gram-positive bacteria than previously known compounds.
Bibliography:Application Number: US19930064078