Acoustic reflection process for molecular sensing using a bulk acoustic wave quartz sensor

• Main Authors: KIPLING; ARLIN L, THOMPSON; MICHAEL
• Format: Patent
• Language: English
• Published: 20.12.1994
• Edition: 5
• Subjects: GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TECHNICAL SUBJECTS COVERED BY FORMER USPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS; TESTING

A passive process for selectively sensing analyte molecules in a fluid by reflection of acoustic waves from a sensing surface of a bulk accoustive wave quartz sensing device to which analyte molecules bind is provided. The sensing surface has a plurality of receptors for which analyte molecules have an affinity. The process has the following steps: i) contacting a fluid in which analyte molecules are suspected with the sensing surface so that acoustic waves are reflected from the sensing surface; ii) directing acoustic waves at the sensing surface; and iii) detecting a change in a characteristic of acoustic waves reflected from the sensing surface due to analyte molecules binding the receptors. The change in a reflected acoustic wave characteristic being measured by electrical means detecting values which are related to the amplitude and phase of the reflected acoustic waves.