Affinity chromatography matrix useful in purifying interleukin-1 beta converting enzyme

Affinity chromatography matrices are disclosed which are useful in purifying interleukin-1(beta) converting enzyme (ICE) from crude or partially purified cell lysate preparations. The chromatographic matrices comprise a specific ICE inhibitor of Formula I which is attached to an affinity column supp...

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Bibliographic Details
Main Authors CHAPMAN; KEVIN T, BULL; HERB G
Format Patent
LanguageEnglish
Published 11.01.1994
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
THEIR RELEVANT APPARATUS
TRANSPORTING
VINEGAR
WINE
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Summary:Affinity chromatography matrices are disclosed which are useful in purifying interleukin-1(beta) converting enzyme (ICE) from crude or partially purified cell lysate preparations. The chromatographic matrices comprise a specific ICE inhibitor of Formula I which is attached to an affinity column support by means of a bifunctional spacer. (* CHEMICAL STRUCTURE *) I
Bibliography:Application Number: US19910746685