Heterocyclic 5-lipoxygenase inhibitors

• Main Authors: DOWELL; ROBERT I, EDWARDS; PHILIP N, OLDHAM; KEITH
• Format: Patent
• Language: English
• Published: 04.01.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention concerns an aryl derivative of the formula I, I wherein Ar1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X1 is a group of the formula -X4-CR2- or -CR2-X4- wherein X4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl; each of Ar2 and Ar3 is optionally substituted phenylene; X2 is oxy, thio, sulphinyl or sulphonyl; R1 is (1-4C)alkyl; and R2 and R3 together form a group of the formula -A1-X3-A2- which together with the carbon atom to which A1 and A2 are attached define a ring having 5 to 7 ring atoms, wherein each of A1 and A2 is (1-3C)alkylene and X3 is oxy, thio, sulphinyl or sulphonyl; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease. The invention concerns an aryl derivative of the formula I, (* CHEMICAL STRUCTURE *) I wherein Ar1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X1 is a group of the formula -X4-CR2- or -CR2-X4- wherein X4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl; each of Ar2 and Ar3 is optionally substituted phenylene; X2 is oxy, thio, sulphinyl or sulphonyl; R1 is (1-4C)alkyl; and R2 and R3 together form a group of the formula -A1-X3-A2- which together with the carbon atom to which A1 and A2 are attached define a ring having 5 to 7 ring atoms, wherein each of A1 and A2 is (1-3C)alkylene and X3 is oxy, thio, sulphinyl or sulphonyl; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease.