Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom

This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such as 1 DEG and 2 DEG amines or reactive thiols that are present o...

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Bibliographic Details
Main Authors MORELAND; MARGARET, GREENFIELD; I. LAWRENCE, NITECKI; DANUTE E
Format Patent
LanguageEnglish
Published 31.08.1993
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
TESTING
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Summary:This invention discloses heterobifunctional coupling agents for making a wide array of molecular conjugates. The agents contain a sterically hindered thiol, linked through a spacer arm to a second group reactive toward nucleophiles such as 1 DEG and 2 DEG amines or reactive thiols that are present on biological and organic materials. The coupling agents are useful for making conjugates containing a sterically hindered linkage.
Bibliography:Application Number: US19920837678