AMINO ACID CONTAINING ACRYLAMIDE DERIVATIVES FOR ULCER PREVENTION OR TREATMENT
Novel acrylic amide derivative of the formula wherein R represents a hydrogen or a halogen atom or a C1-4alkyl, a C1-4alkoxy or a nitro group. n is an integer of 0 to 2, A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the a...
Saved in:
Main Authors | , , , , , , |
---|---|
Format | Patent |
Language | English |
Published |
25.05.1993
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Novel acrylic amide derivative of the formula wherein R represents a hydrogen or a halogen atom or a C1-4alkyl, a C1-4alkoxy or a nitro group. n is an integer of 0 to 2, A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C1-4alkyl group or is amidated; or A represents a group of formula wherein R2 is a hydrogen atom or a phenyl, a C1-4alkyl or a C1-4alkoxycarbonyl group, and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds. |
---|---|
Bibliography: | Application Number: US19900551518 |